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Cholinesterase inhibitors reduce cortical A beta in dementia with Lewy bodies

Lookup NU author(s): Carein ToddORCiD, Professor Ian McKeith, Professor John O'Brien, Emeritus Professor Elaine Perry

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Abstract

Cholinesterase inhibitors (ChEls) are effective symptomatic treatments in dementia with Lewy bodies (DLB), although effects on pathologic mechanisms are unknown. In the first human autopsy study examining the impact of ChEl treatment on brain pathology, we compared treated patients with DLB with matched untreated patients for cortical beta-amyloid (A beta) and tau pathologies. Treated patients with DLB had significantly less parenchymal A beta deposition, which is relevant to disease management and treatment of dementia patients using ChEl.

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Author(s): Ballard CG, Chalmers KA, Todd C, McKeith IG, O'Brien JT, Wilcock G, Love S, Perry EK

Publication type: Article

Publication status: Published

Journal: Neurology

Year: 2007

Volume: 68

Issue: 20

Pages: 1726-1729

ISSN (print): 0028-3878

ISSN (electronic): 1526-632X

Publisher: Lippincott Williams & Wilkins

URL: http://dx.doi.org/10.1212/01.wnl.0000261920.03297.64

DOI: 10.1212/01.wnl.0000261920.03297.64

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