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Interleukins 7 and 12 are expressed in head and neck squamous cancer

Lookup NU author(s): Professor Vinidh Paleri, Dr Anna Pulimood

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Abstract

Interleukin 7 (IL-7) and IL-12 have major roles in cell-mediated turnour immunity. In head and neck squamous cell cancer, depressed cell-mediated immunity is well documented and may account for the poor prognosis. This is the first study to assess intratumour expression of IL-7 and IL-12 in head and neck squamous cell cancer (HNSCC). Immunohistochemistry was used to identify IL-7 and IL-12 expression in snap-frozen tumour specimens from 25 patients with HNSCC and the results of immunohistochemical staining were semiquantitatively graded. Both IL-7 and IL-12 were expressed in all tumour samples and expression was not related to tumour stage or site. A trend towards better survival was associated with high expression of IL-7 and IL-12, this being more pronounced with IL 7. The universal expression suggests that the depressed cell-mediated immunity in HNSCC is not caused by reduced production of IL-7 and IL-12. Further studies with larger cohorts, especially of IL-7, are certainly warranted.

Publication metadata

Author(s): Paleri V, Pulimood A, Davies GR, Birchall MA

Publication type: Article

Publication status: Published

Journal: Clinical Otolaryngology

Year: 2001

Volume: 26

Issue: 4

Pages: 302-306

ISSN (print): 1749-4478

ISSN (electronic): 1749-4486

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1046/j.1365-2273.2001.00475.x

DOI: 10.1046/j.1365-2273.2001.00475.x

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