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Cochlear implantation in patients with MELAS syndrome

Lookup NU author(s): Dr Petros Karkos

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Abstract

MELAS syndrome ( mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes) is a rare congenital disorder of mitochondrial DNA (mt-DNA). Patients with this syndrome may present to the otolaryngologist with sensorineural hearing loss (SNHL) that is genetic in origin. Mitochondrial cytopathies can present with a variety of symptoms, but they occasionally present with SNHL as their first manifestation. Two cases of MELAS patients who responded well to cochlear implantation are presented. A review of the literature is also carried out focusing mainly on diagnosis, anesthetic considerations and management of these patients.

Publication metadata

Author(s): Karkos PD, Anari S, Johnson IJ

Publication type: Article

Publication status: Published

Journal: European Archives of Oto-Rhino-Laryngology

Year: 2005

Volume: 262

Issue: 4

Pages: 322-324

ISSN (print): 0937-4477

ISSN (electronic): 1434-4726

Publisher: Springer

URL: http://dx.doi.org/10.1007/s00405-004-0817-x

DOI: 10.1007/s00405-004-0817-x

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