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Lysosomal redox-active iron is important for oxidative stress-induced DNA damage

Lookup NU author(s): Tino Kurz, Alan Leake, Professor Thomas von Zglinicki

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Abstract

Data show that specifically chelating lysosomal redox-active iron can prevent most H2O2-induced DNA damage. Lysosomes seem to contain the major pool of redox-active labile iron within the cell. Under oxidative stress conditions, this iron may then relocate to the nucleus and play an important role for DNA damage by taking part in Fenton reactions.

Publication metadata

Author(s): Kurz T, Leake A, von Zglinicki T, Brunk UT

Editor(s): De Grey, A.D.N.

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Strategies for Engineered Negligible Senescence: Why Genuine Control of Aging May be Forseeable

Year of Conference: 2004

Pages: 285-288

ISSN: 0077-8923

Publisher: New York Academy of Sciences

URL: http://dx.doi.org/10.1196/annals.1297.048

DOI: 10.1196/annals.1297.048

Library holdings: Search Newcastle University Library for this item

Series Title: Annals of the New York Academy of Sciences

ISBN: 9781573314961

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