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Interaction between cardiac beat-to-beat interval changes an systolic blood pressure changes

Lookup NU author(s): Emma Bowers, Emeritus Professor Alan MurrayORCiD

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Abstract

This study assessed the interaction between cardiac beat-to-beat interval changes and systolic pressure (SP) changes. Twenty subjects breathed regularly following displayed breathing signals at 4, 6, 8, 10, 12 and 14 breaths per minute, each for 5 minutes. ECG, non-invasive blood pressure (Finapres) and respiration waveforms were recorded. Time offsets between the cyclic patterns of RR-interval and SP changes were calculated. Displayed breathing signals were well followed; the mean correlation between displayed and recorded breathing signals ranged from 0.72 to 0.86. The time offset between RR-interval peaks and subsequent SP troughs decreased with increasing respiration rate, 3.8 +/- 1.7 s, 3.5 +/- 0.7 s, 3.1 +/- 0.6 s, 2.6 +/- 0.4 s, 2.3 +/- 0.4 s and 2.0 +/- 0.4 s mean +/- SD at 4,6,8,10,12 and 14 breaths per minute respectively. The relationship between mean time offset and frequency was significant (p < 0.001), with a 95 % prediction interval of +/-0.24 s. Published data showed no relationship between time offset and frequency, with a 95% prediction interval of +/- 2.8 s. However, when the offset definition proposed in this research was applied to these data, a significant relationship (p < 0.01) was evident, with a 95% prediction interval of +/-1.5 s. In conclusion, apparently contradictory previous findings achieve good consensus when a standardized method for presenting results is applied. A delay exists between RR-interval and blood pressure changes, and this delay varies with breathing frequency.

Publication metadata

Author(s): Bowers EJ, Murray A

Publication type: Article

Publication status: Published

Journal: Clinical Autonomic Research

Year: 2004

Volume: 14

Issue: 2

Pages: 92-98

ISSN (print): 0959-9851

ISSN (electronic): 1619-1560

Publisher: Dr. Dietrich Steinkopff Verlag

URL: http://dx.doi.org/10.1007/s10286-004-0169-z

DOI: 10.1007/s10286-004-0169-z

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