Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Radiology review of the UKCCCR breast screening frequency trial: Potential improvements in sensitivity and lead time of radiological signs

Lookup NU author(s): Dr James Young

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

AIM: To review all previous mammograms of breast cancer cases diagnosed during a randomized trial comparing 3 yearly to annual mammographic screening with a view to identifying and quantifying cases that might potentially have been diagnosed earlier. METHODS: Mammograms of 602 breast cancer cases (399 screen-detected and 203 interval cases) were reviewed in chronological order and suspicious radiological features noted for each mammogram, up to and including the diagnostic mammogram. RESULTS: Of the 602 cases, 79 (13%) had features at diagnosis that were visible on previous mammograms, suggesting a sensitivity of interpretation of 87%. A similar proportion of screen-detected (14%) and interval cancers (11%) had signs at diagnosis that were visible on previous mammograms. The potential for improvement was particularly noted for asymmetric density (sensitivity = 77%, average time visible before diagnosis 14 months) and parenchymal deformity/stellate lesion (sensitivity = 81%, average time visible before diagnosis 12 months). CONCLUSION: The highest sensitivity was observed for comedo-type microcalcifications (sensitivity = 97%, average time visible before diagnosis 5 months). By improvements in sensitivity to asymmetric density and parenchymal deformity/stellate lesion, 4% of tumours could have their time of diagnosis advanced substantially. (C) 2003 The Royal College of Radiologists. Published by Elsevier Science Ltd. All rights reserved

Publication metadata

Author(s): Warren RML, Young JR, McLean L, Lyons K, Wilson ARM, Evans A, Duffy SW, Warsi IM

Publication type: Review

Publication status: Published

Journal: Clinical Radiology

Year: 2003

Volume: 58

Issue: 2

Pages: 128-132

ISSN (print): 0009-9260

ISSN (electronic):

URL: http://dx.doi.org/10.1053/crad.2002.1132

DOI: 10.1053/crad.2002.1132

Share