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Recurrence of hemolytic uremic syndrome after live related renal transplantation associated with subsequent de novo disease in the donor

Lookup NU author(s): Dr Rosemary Donne, Dr Margaret Little, Professor Tim Goodship

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Abstract

There is a significant risk of disease recurrence in patients with nondiarrheal (D-) hemolytic uremic syndrome (HUS) undergoing renal transplantation. Recent studies have found that approximately 20% of sporadic cases of HUS have mutations in the gene for the complement regulatory protein factor H. The authors report on 2 families, in each of which a family member initially presented with sporadic HUS and subsequently received a live-related renal transplant, one from a sibling and the other from the father. Subsequently, both recipients suffered recurrent HUS in the allograft, and both donors had HUS within a year of the transplant. Neither family has a factor H mutation. This report underlines the risk of disease recurrence in recipients associated with live-related renal transplantation in HUS and also suggests that the donors may be at risk.

Publication metadata

Author(s): Donne RL; Little M; Goodship THJ; Abbs I; Barany P; Elinder CG; Conlon P

Publication type: Article

Publication status: Published

Journal: American Journal of Kidney Diseases

Year: 2002

Volume: 40

Issue: 6

ISSN (print): 0272-6386

ISSN (electronic): 1523-6838

Publisher: W.B. Saunders Co.

URL: http://dx.doi.org/10.1053/ajkd.2002.36938

DOI: 10.1053/ajkd.2002.36938

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