Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Modelling the influence of thalamo-cortical projections on prefrontal activity

Lookup NU author(s): Paula Nielsen, Klaas Stephan

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Altered connections between the thalamus and the prefrontal cortex are often implicated in theories concerning the pathogenesis of schizophrenia. Using a model based on anatomically realistic connection patterns between thalamus and prefrontal cortex, we analyzed changes of prefrontal activity resulting from stimulation of the mediodorsal thalamus. Here we demonstrate that the specific influence of thalamo-cortical projections is smaller than the importance of intra-prefrontal connectivity in shaping prefrontal activity patterns. These results might be helpful in explaining experimentally observed hypo- and hyperactive states of prefrontal cortex in schizophrenic patients, (C) 2002 Elsevier Science B.V. All rights reserved.

Publication metadata

Author(s): Kamper L, Bozkurt A, Nielsen P, Dyhrfjeld-Johnsen J, Stephan KE, Kotter R

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Neurocomputing: 10th Computational Neuroscience Meeting (CSN 01)

Year of Conference: 2002

Pages: 869-873

ISSN: 0925-2312

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/S0925-2312(02)00485-X

DOI: 10.1016/S0925-2312(02)00485-X

Library holdings: Search Newcastle University Library for this item

ISBN: 18728286

Share