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Studies on alpha(1 -> 5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity

Lookup NU author(s): Dr Sudagar Gurcha, Professor Del Besra

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Abstract

The appearance multi-drug resistant Mycobacterium tuberculosis (MTB) throughout the world has prompted a search for new. safer and more active agents against tuberculosis. Based on studies of the biosynthesis of mycobacterial cell wall polysaccharides, octyl 5-O-(alpha -D-arabinofuranosyl)-alpha -D-arabinofuranoside analogues were synthesized and evaluated as inhibitors for Al. tuberculosis and Mycobacterium avium. A cell free assay system has been used for the evaluation of these disaccharides as substrates for mycobacterial arabinosyltransferase activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

Publication metadata

Author(s): Pathak AK, Pathak V, Maddry JA, Suling WJ, Gurcha SS, Besra GS, Reynolds RC

Publication type: Article

Publication status: Published

Journal: Bioorganic & Medicinal Chemistry

Year: 2001

Volume: 9

Issue: 12

Pages: 3145-3151

ISSN (print):

ISSN (electronic): 1464-3391

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/S0968-0896(01)00180-8

DOI: 10.1016/S0968-0896(01)00180-8

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