Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Immune selection in neoplasia: towards a microevolutionary model of cancer development

Lookup NU author(s): Emmett O'Flaherty, Emeritus Professor John Kirby

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

The dual properties of genetic instability and clonal expansion allow the development of a tumour to occur in a microevolutionary fashion. A broad range of pressures are exerted upon a tumour during neoplastic development. Such pressures are responsible for the selection of adaptations which provide a growth or survival advantage to the tumour. The nature of such selective pressures is implied in the phenotype of tumours that have undergone selection. We have reviewed a range of immunologically relevant adaptations that are frequently exhibited by common tumours. Many of these have the potential to function as mechanisms of immune response evasion by the tumour. Thus, such adaptations provide evidence for both the existence of immune surveillance, and the concept of immune selection in neoplastic development. This line of reasoning is supported by experimental evidence from murine models of immune involvement in neoplastic development. The process of immune selection has serious implications for the development of clinical immunotherapeutic strategies and our understanding of current in vivo models of tumour immunotherapy. (C) 2000 Cancer Research Campaign.

Publication metadata

Author(s): Kirby JA; O'Flaherty E; Pettit SJ; Seymour K

Publication type: Review

Publication status: Published

Journal: British Journal of Cancer

Year: 2000

Volume: 82

Issue: 12

Pages: 1900-1906

ISSN (print): 0007-0920

ISSN (electronic): 1532-1827

URL: http://dx.doi.org/10.1054/bjoc.2000.1206

DOI: 10.1054/bjoc.2000.1206

Share