Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

A prospective study of glycaemic status in anti-psychotic-treated patients

Lookup NU author(s): Dr Paul Mackin, Helen Watkinson, Emeritus Professor Nicol Ferrier

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Anti-psychotic drugs, particularly the second generation, or 'atypical' agents, have been implicated in the development of metabolic dysfunction such as diabetes mellitus. There is a paucity of longitudinal data on the natural history of glucose homeostasis in anti-psychotic-treated patients, and there are no universally accepted strategies for managing worsening glycaemic control in this population. Notwithstanding, several guidelines recommend switching to a 'lower risk' agent if patients develop worsening glycaemic control during anti-psychotic treatment. We prospectively followed a cohort of 106 anti-psychotic-treated patients from across the diagnostic spectrum, and investigated changes in glycaemic status. Between baseline and follow-up assessment (mean follow-up time, 599.3 [SD ± 235.4] days glycaemic status was unchanged in 78 (86.7%) patients; 5 (5.6%) reverted from impaired fasting glucose (IFG) to normoglycaemia in the absence of any pharmacological or lifestyle intervention and all were taking a 'high risk' drug (clozapine or olanzapine). These preliminary data suggest that progression to overt diabetes mellitus is not inevitable in patients who develop IFG during anti-psychotic treatment. Switching to another agent simply on the basis of the development of IFG may not offer any advantage, especially if the mental state is stable. © 2008 British Association for Psychopharmacology.

Publication metadata

Author(s): Mackin P, Bishop D, Watkinson HM, Ferrier IN

Publication type: Article

Publication status: Published

Journal: Journal of Psychopharmacology

Year: 2008

Volume: 22

Issue: 5

Pages: 563-566

ISSN (print): 0269-8811

ISSN (electronic): 1461-7285

Publisher: Sage Publications Ltd.

URL: http://dx.doi.org/10.1177/0269881107081532

DOI: 10.1177/0269881107081532

Altmetrics

Altmetrics provided by Altmetric

Share