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A follow-up study of children hospitalised with community-acquired pneumonia

Lookup NU author(s): Dr Katherine Eastham, Donna Hammal, Professor Louise Parker, Dr David Spencer

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Abstract

Objective: To investigate the outcome for children hospitalised with radiologically confirmed community-acquired pneumonia (CAP) Design: Controlled follow-up study. Setting: Community based in Newcastle upon Tyne, North Tyneside and Northumberland schools. Patients: 103 cases of radiologically confirmed CAP a median of 5.6 years (range 4.4-7.4) after admission to Newcastle General Hospital, matched for sex and school class to a mean of two controls (n = 248). Interventions: A respiratory questionnaire, clinical examination and spirometry measurements. Main outcome measures: Multiple regression was used to describe associations between explanatory variables, including CAP, and outcome variables: forced expiratory volume in 1 s percent predicted (FEV1 %), forced vital capacity percent predicted (FVC %), persistent cough, doctor diagnosis of asthma and abnormal chest shape. Results: Cases were 2.9 times more likely (95% CI 1.45 to 5.71, p = 0.020) than controls to have persistent cough and 5.5 times more likely to have an abnormal chest shape (95% CI 1.65 to 18.28, p = 0.005). Cases of an atopic parent had a 7.0% deficit in FEV1 % predicted (95% CI -10.5 to -3.2, p<0.001) and a 4.4% deficit in FVC % predicted (95% CI -8.0 to -0.78, p = 0.017), but were not at increased risk of subsequent asthma. Cases of a non-atopic parent were at increased risk of subsequent asthma (OR 4.8, 95% CI 1.43 to 16.34, p = 0.011) but not of deficit in lung function. Conclusions: CAP requiring admission to hospital is associated with deficits in lung function and persistent respiratory symptoms. This has implications for follow-up for which recommendations are currently lacking. Parental atopy may be a determinant of outcome.

Publication metadata

Author(s): Eastham KM, Hammal DM, Parker L, Spencer DA

Publication type: Article

Publication status: Published

Journal: Archives of Disease in Childhood

Year: 2008

Volume: 93

Issue: 9

Pages: 755-759

Date deposited: 08/06/2010

ISSN (print): 0003-9888

ISSN (electronic): 1468-2044

Publisher: BMJ Group

URL: http://dx.doi.org/10.1136/adc.2007.128900

DOI: 10.1136/adc.2007.128900

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