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The impact of guideline compliant medical therapy on clinical outcome in patients with stable angina: Findings from the Euro Heart Survey of stable angina

Lookup NU author(s): Dr David Julien

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Abstract

Aims: The European Society of Cardiology published guidelines for the management of stable angina in 1997, with the objective of promoting an evidence-based approach to the condition. This study focuses on the impact of guideline compliant medical treatment on clinical outcome in patients with stable angina. Methods and results: The Euro Heart Survey of Stable Angina is a multicentre prospective observational study conducted between 2002 and 2003. Patients with a clinical diagnosis of stable angina by a cardiologist were enrolled and follow-up was conducted at 1 year. The primary outcome of interest was death or myocardial infarction (MI). The increasing intensity of guideline compliant medical therapy was quantified by means of a simple treatment score based on the use of guideline advocated therapies: antiplatelets, statins, and beta-blockers. A total of 3779 patients were included in the initial survey. Increasing intensity of guideline compliant therapy at initial assessment was associated with a reduction in death and MI during follow-up in patients with angina and confirmed coronary disease (HR 0.68; 95% CI 0.49-0.95 per unit increase in treatment score). All cardiovascular events were also significantly reduced in this subgroup (HR 0.82; 95% CI 0.69-0.97). The benefits of guideline compliant therapy were only observed in patients with objective evidence of coronary disease. Conclusion: Guideline compliant medical therapy improves clinical outcome in patients with stable angina and objective evidence of coronary disease. © The European Society of Cardiology 2006. All rights reserved.

Publication metadata

Author(s): Daly C, Clemens F, Lopez-Sendon JL, Tavazzi L, Boersma E, Danchin N, Delahaye F, Gitt A, Julian D, Mulcahy D, Ruzyllo W, Thygesen K, Verheugt F, Fox KM

Publication type: Article

Publication status: Published

Journal: European Heart Journal

Year: 2006

Volume: 27

Issue: 11

Pages: 1298-1304

ISSN (print): 0195-668X

ISSN (electronic): 1520-765X

Publisher: Oxford University Press

URL: http://dx.doi.org/10.1093/eurheartj/ehl005

DOI: 10.1093/eurheartj/ehl005

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