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Childhood acute lymphoblastic leukaemia in relation to population mixing around the time of birth in South Hungary

Lookup NU author(s): Dr Tibor Nyari, Professor Louise Parker

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Abstract

In a retrospective epidemiological study of 481,984 live births in South Hungary, we investigated whether higher levels of population mixing around the time of birth is a risk factor for acute lymphoblastic leukemia (ALL) under age 5 years. Poisson regression was used to investigate the relationship between risk of ALL and the population-mixing index based on the number of incomers in each county district for each year, standardized to have a range of 0-1. Among all children, the risk of ALL increased significantly with increasing population mixing around the time of birth (trend across the range of 0-1 RR = 2.1 95% Cl: 1.02-4.44). This effect was more marked for boys (RR = 3.1 95% Cl: 1.13-8.51), which supports a sex-specific effect of exposures on risk of ALL. © 2006 Wiley-Liss, Inc.

Publication metadata

Author(s): Nyari TA, Kajtar P, Bartyik K, Thurzo L, Parker L

Publication type: Article

Publication status: Published

Journal: Pediatric Blood and Cancer

Year: 2006

Volume: 47

Issue: 7

Pages: 944-948

ISSN (print): 1545-5009

ISSN (electronic): 1545-5017

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/pbc.20737

DOI: 10.1002/pbc.20737

PubMed id: 16421899

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