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Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity

Lookup NU author(s): Professor Alexander Burkle, Alan Leake, Dr Marie-Laure Muiras, Ragen Pfeiffer

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Abstract

Cellular DNA repair activities can be expected to control the rate of the ageing process by keeping the steady-state levels of DNA damage, which is continuously induced by endogenous and exogenous damaging agents, at low levels. Poly(ADP-ribosyl)ation is one of the immediate biochemical reactions of eukaryotic cells to DNA damage and is functionally associated with DNA base-excision repair and strand break repair. Here we review the current state of the art concerning the relationship between DNA strand break repair, poly(ADP-ribosyl)ation, maintenance of genomic stability and mammalian life span. © 2002 Published by Elsevier Science Inc.

Publication metadata

Author(s): Burkle A, Beneke S, Brabeck C, Leake A, Meyer R, Muiras M-L, Pfeiffer R

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: 2nd Euroconference on Biological Ageing

Year of Conference: 2002

Pages: 1203-1205

ISSN: 0531-5565

Publisher: Experimental Gerontology, Elsevier

URL: http://dx.doi.org/10.1016/S0531-5565(02)00144-4

DOI: 10.1016/S0531-5565(02)00144-4

PubMed id: 12470832

Library holdings: Search Newcastle University Library for this item

ISBN: 18736815

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