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Low-threshold N-methyl-D-aspartate receptor function correlates negatively with learning

Lookup NU author(s): Professor Philip Bradley, Dr Alison Webb

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Abstract

The intermediate, medial hyperstriatum ventrale (IMHV) is an area of the forebrain of the domestic chick which exhibits great plasticity. Moreover, there is a strong link between plasticity in the IMHV and specific changes in behaviour. The IMHV in vitro is still plastic, and many of its physiological properties are age-dependent, peaking in slices taken from 3- or 4-day-old birds. This 'window' coincides with an important transitional period in a chick's normal behavioural development. It has also been claimed that reversal training is at its most effective in 3- and 4-day-old birds - a proposition which was confirmed by the experiments reported here. A combination of in vivo training followed by in vitro electrophysiology also revealed that the function of low-threshold N-methyl-D-aspartate receptors (one of the age-related variables) is negatively related to the effectiveness of reversal training, when age is held constant. © 2001 Elsevier Science B.V.

Publication metadata

Author(s): Bradley PM, Burns BD, Webb AC

Publication type: Article

Publication status: Published

Journal: Brain Research

Year: 2001

Volume: 900

Issue: 1

Pages: 38-47

ISSN (print): 0006-8993

ISSN (electronic): 1872-6240

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/S0006-8993(01)02172-2

DOI: 10.1016/S0006-8993(01)02172-2

PubMed id: 11325344

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