Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Merkel cell carcinoma can be distinguished from metastatic small cell carcinoma using antibodies to cytokeratin 20 and thyroid transcription factor 1

Lookup NU author(s): Dr Suzy Leech, Dr Niamh Leonard

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Aim - To investigate whether immunohistochemical staining for cytokeratin 20 (CK20) and thyroid transcription factor 1 (TTF-1) is useful in distinguishing Merkel cell carcinomas (MCCs) from metastatic small cell carcinomas (SCCs). Methods - Eleven cases of MCC and 10 of lung SCC were stained for CK20 and TTF-1. Results - Ten of 11 MCCs stained with the antibody to CK20. None was positive for TTF-1. No SCC stained with anti-CK20 and all stained strongly with anti-TTF-1. Conclusions - The use of both anti-CK20 and anti-TTF-1 can reliably distinguish between MCC and metastatic SCC, thus avoiding the need for a detailed clinical investigation of patients with MCC in whom metastatic SCC must be excluded.

Publication metadata

Author(s): Leech SN; Leonard N; Kolar AJO; Barrett PD; Sinclair SA

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Pathology

Year: 2001

Volume: 54

Issue: 9

Pages: 727-729

ISSN (print): 0021-9746

ISSN (electronic):

Publisher: BMJ Publishing Group

URL: http://dx.doi.org/10.1136/jcp.54.9.727

DOI: 10.1136/jcp.54.9.727

PubMed id: 11533085

Altmetrics

Altmetrics provided by Altmetric

Share