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The oestrogen receptors (ERα and ERβ) and their role in breast cancer: A review

Lookup NU author(s): Fiona Girdler, Dr Ian Brotherick

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Abstract

One of the main prognostic markers measured in breast tumours is oestrogen receptor (ER) status. With the discovery of ERβ, it has been necessary to re-evaluate ER signalling and the role of ER in breast cancer. Preliminary reports on ERβ signalling suggest it might induce opposite effects to those of ERα. To further understand the biology of breast cancer, the role each ER plays in disease progression must be established. This review summarizes the current understanding of ERβ and discusses some of the published work on the role of ERα and ERβ in breast cancer. (C) 2000 Harcourt Publishers Ltd.

Publication metadata

Author(s): Girdler F, Brotherick I

Publication type: Article

Publication status: Published

Journal: Breast

Year: 2000

Volume: 9

Issue: 4

Pages: 194-200

ISSN (print): 0960-9776

ISSN (electronic): 1532-3080

Publisher: Churchill Livingstone

URL: http://dx.doi.org/10.1054/brst.2000.0203

DOI: 10.1054/brst.2000.0203

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