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Association of HLA-DRB1 alleles with giant cell tumour of bone

Lookup NU author(s): Satya Varanasi, Dr Surinder Papiha, Dr Harish Datta

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Abstract

Aim - To examine the possible influence of the MHC class II antigens alleles in the formation of the multinucleate aggressive giant cell tumour of bone. Methods - HLA class II antigen alleles were investigated in eight white patients from north east England with confirmed diagnosis of giant cell tumour of bone. All had locally aggressive, immunophenotypically HLA-DR negative giant cell tumours. Results - Five of the eight patients were found to be positive for HLA-DRB1*0801/3, the distribution of this allele in healthy white controls being quite low (2%). All but one of the patients possessing DRB1*080 also expressed DRB1*070. Conclusions - HLA-DRB1*080 is predominant in patients with immunophenotypic HLA-DR negative giant cell tumour of bone; individuals with the genotype 070/080 are at particularly high risk of developing giant cell tumour of bone.

Publication metadata

Author(s): Varanasi SS, Athanasou NA, Briceno I, Papiha SS, Datta HK

Publication type: Article

Publication status: Published

Journal: Journal of Clinical Pathology

Year: 1999

Volume: 52

Issue: 10

Pages: 782-784

Print publication date: 01/10/1999

ISSN (print): 0021-9746

ISSN (electronic):

Publisher: B M J Group

URL: http://dx.doi.org/10.1136/jcp.52.10.782

DOI: 10.1136/jcp.52.10.782

PubMed id: 10674041

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