Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Oncological outcomes following left-sided pancreatic resection for grade 1 and grade 2 pancreatic neuroendocrine tumours: a population-cohort study comparing open with minimally-invasive surgery

Lookup NU author(s): Abdullah MalikORCiD, Dr Sam Tingle, Steven White, Professor Sanjay PandanaboyanaORCiD

Downloads

Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2026 The Authors. Background: Minimally invasive left-sided pancreatectomy (MIS-LP) is increasingly adopted for resection of grade 1 and 2 pancreatic neuroendocrine tumours (PNETs), but its oncological equivalence to open left-sided pancreatectomy (O-LP) remains to be fully evaluated. Methods: We conducted a retrospective cohort study using SEER-Medicare data (2010–2019) including all patients who underwent left-sided pancreatectomy (LP) for PNETs. A multilevel Cox regression model was used to to provide adjusted hazard ratios (HR) for overall survival (OS) and cancer-specific survival (CSS) when comparing between MIS-LP and O-LP. A 6-month landmark survival analysis was performed to account for early postoperative deaths. Results: A total of 772 patients were included, with 257 (33.3%) undergoing MIS-LP. Six-hundred-and-seventy-two patients had grade 1, and 100 patients had grade 2 PNETs. MIS-LP was associated with better OS (HR 0.48, 95% CI 0.26-0.86, P=0.014) and CSS (HR 0.35, 95% CI 0.14-0.88, P=0.026). In the 6-month landmark analysis, O-LP was associated with similar OS and CSS to MIS-LP. Conclusion: MIS-LP is associated with improved early survival compared to O-LP in patients with low- to intermediate-grade PNETs.

Publication metadata

Author(s): Malik AK, Chang Y-HH, Tingle SJ, White SA, Qadan M, Fong ZV, Pandanaboyana S

Publication type: Article

Publication status: Published

Journal: HPB

Year: 2026

Pages: Epub ahead of print

Online publication date: 12/07/2026

Acceptance date: 04/07/2026

Date deposited: 03/08/2026

ISSN (print): 1365-182X

ISSN (electronic): 1477-2574

Publisher: Elsevier BV

URL: https://doi.org/10.1016/j.hpb.2026.07.003

DOI: 10.1016/j.hpb.2026.07.003

Altmetrics

Altmetrics provided by Altmetric

Funding

Funder referenceFunder name
MRC Clinical Research Training Fellowship (MR/Z50502X/1)

Share