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Human brain slice culture model of STXBP1 encephalopathy reveals disruption of neuronal network activity and changes in gene expression

Lookup NU author(s): Dr Faye McLeodORCiD, Anna Dimtsi, Dr Michael SavageORCiD, YenChi Tan, Professor Andrew Trevelyan, Dr Gavin ClowryORCiD

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Author(s): McLeod F, Dimtsi A, Savage MA, Tan YC, Hedley A, Trevelyan AJ, Clowry GJ

Publication type: Article

Publication status: Published

Journal: Experimental Neurology

Year: 2026

Volume: 404

Print publication date: 01/10/2026

Online publication date: 28/05/2026

Acceptance date: 26/05/2026

Date deposited: 22/06/2026

ISSN (print): 0014-4886

ISSN (electronic): 1090-2430

Publisher: Academic Press Inc.

URL: https://doi.org/10.1016/j.expneurol.2026.115855

DOI: 10.1016/j.expneurol.2026.115855

Data Access Statement: All data generated or analysed and used in this study are available upon reasonable request.

PubMed id: 42214744

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