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Lookup NU author(s): Dr Emmanuel Ogundimu, Dr Matt BawnORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
Non-typhoidal Salmonella (NTS) causes approximately 155,000 deaths annually and poses significant risks to both human and animal health. Antimicrobial resistance (AMR) in NTS is a growing global public health threat. Using a One Health approach, this study investigated NTS in swine, poultry and wastewater in Gauteng Province, South Africa. From May 2019 to August 2020, 507 samples were collected. Whole genome sequencing identified a 2.37% NTS prevalence, including multidrug-resistant monophasic S. Typhimurium ST34. The strains showed ASSuT resistance and represent the first detection of ST34 from an animal source in Africa. Phylogenetic analysis linked these strains to human cases in South Africa and the UK, suggesting possible transmission between animals and humans and highlighting the need for enhanced AMR surveillance.
Author(s): Ogundare ST, Thilliez G, Bawn M, Makumbi J-P, Hamiwe T, Fasina FO, Smith AM, van der Zel GA, Kock MM, Geertsma PF, Ehlers MM
Publication type: Article
Publication status: Published
Journal: npj Antimicrobials and Resistance
Year: 2025
Volume: 3
Online publication date: 03/11/2025
Acceptance date: 25/09/2025
Date deposited: 17/06/2026
ISSN (electronic): 2731-8745
Publisher: Springer Nature
URL: https://doi.org/10.1038/s44259-025-00159-3
DOI: 10.1038/s44259-025-00159-3
Data Access Statement: The nucleotide sequences of all strains detected in this study have been deposited in the NCBI under BioProject ID PRJNA1170267 and accession numbers SAMN44102839, SAMN44102838, SAMN44102837, SAMN44102836, SAMN44102835, SAMN44102834, SAMN44102833, SAMN44102832, SAMN44102831, SAMN44102830, SAMN44102829, and SAMN44101722. Additional data generated or analysed during this study are provided in the strain-associated figures in the Appendix.
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