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Developing a Virtual Research Environment in the Parkinson's Progression Markers Initiative: myPPMI

Lookup NU author(s): Professor Nicola PaveseORCiD

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Abstract

© 2026 American Neurological Association.In the 15 years since Parkinson's Progression Markers Initiative (PPMI) launched, research conduct has advanced with broader connectivity, enabling virtual and hybrid methods for recruitment, engagement, education, and data collection. To meet evolving needs, PPMI created “myPPMI,” which has grown from an informational portal to a multi-country, participant-centered, virtual research environment integrating education, screening, e-consent, longitudinal non-motor and motor assessments, and biospecimen referral. Built on a secure, cloud-native architecture with daily analytics and a multi-tier support model, myPPMI enables precision recruitment, real-time eligibility matching, and standardized low-burden data capture across studies. The platform is designed to enable focused data collection from individuals or groups based on the data they have already provided. This strategy provides the tools to establish precise subsets of high interest that could be targeted for further data acquisition. Usability testing and rapid global scaling demonstrate a generalizable, decentralized framework for biomarker-driven, Parkinson's disease research. ANN NEUROL 2026.

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Author(s): Stanley CE, McMahon BA, Matthews-McGee A, Fitzgerald C, Singh Z, Rigby NH, Talarico J-M, Brown EG, Korell M, McGuire Kuhl M, Destro C, Pavese N, Garrido A, Mollenhauer B, Chowdhury S, Marek K, Tanner CM, Tropea TF, Marek K, Simuni T, Siderowf A, Tanner C, Tropea TF, Foroud T, Chahine L, Mollenhauer B, Merchant K, Galasko D, Coffey C, Poston K, Dobkin R, Brown E, Alcalay R, Weintraub D, Flagg E, Bressman S, Blauwendraat C, Casalin P, Dumanis S, James R, Kieburtz K, Mantri S, Poewe W, Schwarzschild M, Seibyl J, Standaert D, Tosun-Turgut D, Chowdhury S, Eberling J, Frasier M, Kirsch L, Kopil K, Kuhl M, O'Grady A, Sherer T, Willson T, Flagg E, Simuni T, McMahon B, Stanley C, Fabrizio K, Fabrizio K, Fabrizio K, Ecklund D, Kohnen C, Foroud T, Heathers L, Hobbick C, Antonopoulos G, Seibyl J, Poston K, Coffey C, Caspell-Garcia C, Brumm M, Toga A, Crawford K, Hamer J, Mollenhauer B, Galasko D, Merchant K, Singleton A, Keene D, Tanner C, Brown E, Tanner C, Brown E, Chahine L, Dobkin R, Korell M, Prakash N, Simuni T, Dahodwala N, Tanner C, Chahine L, Mollenhauer B, Schade S, Galasko D, Mirelman A, Alcalay R, Leaver K, Saint-Hilaire M, Schneider R, Tarolli C, Poewe W, Videnovic A, Standaert D, Dean M, Jonsdottir S, Krueger R, Pauly C, Factor S, Hogarth P, Hauser R, Amara A, Fullard M, Zabetian C, Fernandez H, Brockmann K, Wurster I, Tai Y, Barone P, Picillo M, Isaacson S, Espay A, Tolosa E, Martinez JR, Stefanis L, Chou K, Kalia L, Marras C, Grimes D, Mestre T, Pahwa R, Lew M, Shill H, Mehta S, Riboldi G, McFarland N, Postuma R, Mari Z, Ledingham D, Pavese N, Hu M, Brueggemann N, Klein C, Bloem B, Simonet C, Noyce A, Janzen A, Pedrosa D, Oertel W, Okubadejo N, Shprecher D, Tarakad A, Moukheiber E, Antala J, Aranda C, Williams K, Melton S, Benson K, Ramachandran A, Potts D, LaMoure G, Vengadesh R, Manzler R, Heller J, Ranola P, Kausar F, Mosovsky S, Willeke D, Gomez EK, Rodriguez J, Kemmotsu N, Eshel M, Raymond D, Desrosiers A, James R, Jackson L, Egner I, Schlett W, Blair C, Ruffrage L, Sevilla B, Sommerfeld B, Le D, Botting E, Mazur G, Derlein D, Doll E, Liu Y, Cobb C, Masiewicz O, Mule J, Morsillo M, Hilt E, Jakiran A, Valentino D, Pennente L, Stubbeman B, Garrido A, Ravasi V, Croitoru I, Koros C, Papagiannakis N, Ferrari F, Zheng M, Reddie S, Alejandra A, Gray A, Valenzuela A, Goodman C, Dresler S, Santos N, Esha F, Rizer K, Zablith N, Dumitrescu L, Galley D, Foster VK, Razzaque J, Grummer M, Krasowski Y, Donkor N, Sittig E, Ojo O, Clark K, Mahabir R, Ribb K, Willoughby S

Publication type: Editorial

Publication status: Published

Journal: Annals of Neurology

Year: 2026

Pages: epub ahead of print

Online publication date: 21/04/2026

Acceptance date: 20/03/2026

ISSN (print): 0364-5134

ISSN (electronic): 1531-8249

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1002/ana.78230

DOI: 10.1002/ana.78230

PubMed id: 42015362

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