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Towards high-quality and timely interim analyses in adaptive trials: a scoping review of best practice and evidence gaps

Lookup NU author(s): Dr Katie ThomsonORCiD, Dr Opeyemi AgbeleyeORCiD, Chizoba OparahORCiD, Alex InskipORCiD, Dr Matthew Breckons, Michelle Bardgett, Alex Bevin-Nicholls, Professor Helen HancockORCiD, Helen MossopORCiD, Julia PhillipsonORCiD, Emerita Professor Dawn Teare, Zoe WalmsleyORCiD, Dr Nina WilsonORCiD, Professor Dawn CraigORCiD, Professor James WasonORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Publication metadata

Author(s): Thomson KH, Agbeleye O, Oparah C, Inskip A, Breckons M, Bardgett M, Bevin-Nicholls A, Hancock H, Mossop H, Phillipson J, Teare D, Walmsley Z, Wilson N, Craig D, Wason JMS

Publication type: Article

Publication status: Published

Journal: Trials

Year: 2026

Volume: 27

Print publication date: 30/04/2026

Online publication date: 21/03/2026

Acceptance date: 11/03/2026

Date deposited: 30/04/2026

ISSN (electronic): 1745-6215

Publisher: BioMed Central Ltd.

URL: https://doi.org/10.1186/s13063-026-09643-1

DOI: 10.1186/s13063-026-09643-1

Data Access Statement: The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

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Funding

Funder referenceFunder name
JW is funded by a NIHR Research Professorship (NIHR301614)
The ROBIN project was funded by the National Institute for Health & Care Research (NIHR) CTU Support Funding scheme.

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