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Androgen receptor splice variant 7 expression levels distinguish AR-mutated from nonmutated metastatic castration-resistant prostate cancers

Lookup NU author(s): Professor Francisco FigueiredoORCiD, Dr Nicholas BrittainORCiD, Dr Laura WalkerORCiD, Dr Luke GaughanORCiD

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Author(s): Paschalis A, Figueiredo I, Bogdan D, Lundberg A, Santos R, Gurel B, Taha T, Longoria O, Ferreira A, Bertan C, Brittain N, Nelson R, Walker L, Neeb A, Welti J, Yuan W, Mitsopoulos C, Plymate SR, Haffner MC, Sowalsky AG, Carreira S, Sharp A, Gaughan L, de Bono J

Publication type: Article

Publication status: Published

Journal: The Journal of Clinical Investigation

Year: 2026

Volume: 136

Issue: 7

Print publication date: 01/04/2026

Online publication date: 01/04/2026

Acceptance date: 02/03/2026

Date deposited: 21/04/2026

ISSN (print): 0021-9738

ISSN (electronic): 1558-8238

Publisher: American Society for Clinical Investigations

URL: https://doi.org/10.1172/JCI198193

DOI: 10.1172/JCI198193

Data Access Statement: All data values are included in the Supporting Data Values file. Transcriptomic and targeted sequencing datasets used in this study have been previously published and made available (29, 30, 36). The RMH transcriptomic cohort data are available via EGA accession number: EGAS50000001269 (28). The SU2C cohort data are avail- able in cBioPortal and on GitHub under the code prad_su2c_2019. The WCDT cohort data are available on dbGaP with study num- ber phs001648. The code used in this manuscript is available at: https://github.com/arianlundberg/AR_splicing.

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