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Lookup NU author(s): Emeritus Professor David Brooks, Professor Nicola PaveseORCiD
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
© 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Background: Neuroinflammation, measured using [11C](R)-PK11195 positron emission tomography (PET), has been reported in isolated rapid-eye-movement sleep behavior disorder (iRBD), but its temporal progression is unknown. Objective: The aim was to assess longitudinal progression of neuroinflammation in iRBD patients and its relationship with phenoconversion into Parkinson's disease (PD) or dementia with Lewy bodies (DLB). Methods: Sixteen iRBD patients received longitudinal [11C](R)-PK11195 PET scans over 3 years and were followed up clinically for 8 years to record phenoconversion into PD and DLB. Results: We found significant progression of neuroinflammation in the putamen among other regions, with a trend to cortical increase over 3 years. During the clinical follow-up, 7 patients converted, and subgroup analyses suggested that the converters differed in progression patterns, with PD converters exhibiting increases and DLB exhibiting decreases in inflammation. Conclusion: This exploratory study suggests that progression of neuroinflammation in iRBD patients depends on their clinical trajectories, and this could be impactful in immune-modifying treatments. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Author(s): Baun AM, Iranzo A, Terkelsen MH, Hinz R, Stokholm MG, Staer K, Serradel M, Otto M, Svendsen KB, Garrido A, Vilas D, Moller A, Gaig C, Tolosa E, Brooks DJ, Borghammer P, Eskildsen SF, Pavese N
Publication type: Article
Publication status: Published
Journal: Movement Disorders
Year: 2026
Pages: epub ahead of print
Online publication date: 12/03/2026
Acceptance date: 18/02/2026
Date deposited: 24/03/2026
ISSN (print): 0885-3185
ISSN (electronic): 1531-8257
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1002/mds.70265
DOI: 10.1002/mds.70265
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