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Immune reset and immune retune: approaching cure?

Lookup NU author(s): Professor John IsaacsORCiD

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Abstract

© Springer Nature Limited 2026. The emergence of potent depletion therapies for the treatment of refractory autoimmunity has led to the concept of immune reset. Understanding whether immune reset equates to cure, and whether cure is achievable through non-depleting approaches, depends on the identification of immune biomarkers for measuring healthy and pathological immunity.

Publication metadata

Author(s): Isaacs JD

Publication type: Note

Publication status: Published

Journal: Nature Reviews Rheumatology

Year: 2026

Volume: 22

Pages: 215-217

Print publication date: 01/04/2026

Online publication date: 16/02/2026

Acceptance date: 02/04/2018

ISSN (print): 1759-4790

ISSN (electronic): 1759-4804

Publisher: Nature Research

URL: https://doi.org/10.1038/s41584-026-01357-7

DOI: 10.1038/s41584-026-01357-7

PubMed id: 41699070

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