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Distinct immunity protein families mediate compartment-specific neutralization of a bacterial toxin

Lookup NU author(s): Dr Felicity AlcockORCiD, Dr Yaping YANGORCiD, Dr Guillermina Casabona, Dr Chriselle Mendonca, Dr Fatima Ulhuq, Professor Tracy Palmer FRS FRSE FMedSciORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Publication metadata

Author(s): Alcock F, Yang Y, Deme J, Casabona G, Mendonca C, Ulhuq F, Lea S, Palmer T

Publication type: Article

Publication status: Published

Journal: Cell Reports

Year: 2025

Volume: 44

Issue: 11

Print publication date: 25/11/2025

Online publication date: 22/10/2025

Acceptance date: 01/10/2025

Date deposited: 27/10/2025

ISSN (electronic): 2211-1247

Publisher: Cell Press

URL: https://doi.org/10.1016/j.celrep.2025.116459

DOI: 10.1016/j.celrep.2025.116459

Data Access Statement: •Cryo-EM data of the EsxX-ExiA-ExiB complex have been deposited at the Electron Microscopy Data Bank (EMDB) Database as EMD-72654 (https://www.ebi.ac.uk/emdb/EMD-72654) and are publicly available as of the date of publication. •All other data reported in this paper will be shared by the lead contact upon request. •This paper does not report original code. •Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.


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Funding

Funder referenceFunder name
10183/Z/15/Z
224151/Z/21/Z
Center for Cancer Research
China Scholarship Council
Intramural Research Program of the NIH
NCI
Wellcome Trust

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