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Investigating the ageing-Parkinson’s disease nexus: standardisation of in vitro models and techniques by the PD-AGE network

Lookup NU author(s): Professor Viktor KorolchukORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© The Author(s) 2025.Ageing is the primary risk factor for Parkinson’s disease, yet the intricate interplay between these processes remains ambiguous. This position paper, a collaborative output from the PD-AGE consortium, addresses the urgent need for standardising methods in in vitro modelling. A panel of international experts recommends human induced pluripotent stem cell (iPSC)-derived models, with chemically induced ageing methods, such as the SLO cocktail, as a robust system. Furthermore, the consortium highlights the value of direct and semi-direct reprogramming for retaining donor-specific ageing phenotypes. The paper also outlines a prioritised panel of measurable parameters, categorised into senescence, inflammaging, omics profiling, and mitochondrial dysfunction, providing a consistent framework to enhance research reproducibility, investigating the nexus of ageing and Parkinson’s. In addition, we provide links to SOPs (https://doi.org/10.5281/zenodo.15056603) [1] to measure the key measurable ageing parameters outlined in this review to facilitate consistency and reproducibility within the field.

Publication metadata

Author(s): Bury AG, Olejnik A, Tocco C, Saurat N, Stephen E, Hockemeyer D, Schwamborn JC, Studer L, Mastroberardino PG, Bolognin S, Kunath T, Korolchuk VI, Drouin-Ouellet J, Mortiboys H

Publication type: Review

Publication status: Published

Journal: npj Parkinson's Disease

Year: 2025

Volume: 11

Issue: 1

Online publication date: 09/10/2025

Acceptance date: 27/08/2025

ISSN (electronic): 2373-8057

Publisher: Nature Research

URL: https://doi.org/10.1038/s41531-025-01137-2

DOI: 10.1038/s41531-025-01137-2

Data Access Statement: No datasets were generated or analysed during the current study.

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