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The last resort antibiotic daptomycin exhibits two independent antibacterial mechanisms of action

Lookup NU author(s): Dr Jess ButtressORCiD, Jessica Wheatley, Dr Katarzyna MickiewiczORCiD, Professor Henrik Strahl von SchultenORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Publication metadata

Author(s): Buttress JA, Schäfer A-B, Koh A, Wheatley J, Mickiewicz K, Wenzel M, Strahl H

Publication type: Article

Publication status: Published

Journal: Nature Communications

Year: 2025

Volume: 16

Online publication date: 24/11/2025

Acceptance date: 06/10/2025

Date deposited: 09/10/2025

ISSN (electronic): 2041-1723

Publisher: Springer Nature

URL: https://doi.org/10.1038/s41467-025-65287-w

DOI: 10.1038/s41467-025-65287-w

Data Access Statement: Source data for all figures and graphs presented in the manuscript are available via Newcastle University's research data repository at https://doi.org/10.25405/data.ncl.29656607. The strains and plasmids are available upon request to H.S.

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Funding

Funder referenceFunder name
Biotechnology and Biological Sciences Research Council (BBSRC) grant BB/X003035/1
BB/S00257X/1Biotechnology and Biological Sciences Research Council (BBSRC)
Medical Research Council (MRC) DTP Studentship MR/N013840/1
Medical Research Council (MRC) DTP Studentship MR/W006944/1
UKRI Future Leaders Fellowship MR/W009587/1

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