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The cholinergic system in dementia with Lewy bodies

Lookup NU author(s): Dr Sahana Sathyanarayana, Professor Nicola PaveseORCiD, Dr David Ledingham

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Abstract

© 2025 Elsevier B.V. Dementia with Lewy bodies (DLB) is a progressive neurodegenerative disorder pathologically characterized by the presence of neuronal intracytoplasmic inclusions known as Lewy bodies. Core clinical features include fluctuating cognitive impairment, recurrent visual hallucinations, REM sleep behavior disorder, and Parkinsonism. Cholinergic dysfunction is implicated in many of the symptoms of DLB, based on both pathologic and functional imaging studies, as well as the clear symptomatic response of cognitive and behavioral symptoms to drugs that modulate the cholinergic system. In this chapter, we will review and discuss the evidence for cholinergic dysfunction in DLB and its clinical and therapeutic implications.

Publication metadata

Author(s): Sathyanarayana S, Pavese N, Ledingham D

Editor(s): Cuello AC

Publication type: Book Chapter

Publication status: Published

Book Title: Cholinergic Involvement in Neurodegenerative Diseases

Year: 2025

Volume: 211

Pages: 231-245

Print publication date: 13/06/2025

Online publication date: 06/05/2025

Acceptance date: 02/04/2025

Series Title: Handbook of Clinical Neurology

Publisher: Elsevier BV

Place Published: Amsterdam

URL: https://doi.org/10.1016/B978-0-443-19088-9.00008-1

DOI: 10.1016/B978-0-443-19088-9.00008-1

Library holdings: Search Newcastle University Library for this item

ISBN: 9780443190889

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