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Central auditory abilities are associated with cognitive and structural neuroimaging markers of Alzheimer’s disease dementia

Lookup NU author(s): Dr Meher Lad, Professor Tim GriffithsORCiD, Professor John-Paul TaylorORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2024 The Alzheimer's Association. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. BACKGROUND: Hearing loss is associated with cognitive and neuroimaging markers of Alzheimer's disease dementia but it is unclear how specific measures relate to these after accounting for a range of hearing abilities. METHOD: 200 participants (155 cognitively normal, 25 mild cognitively impaired and 20 Alzheimer's disease dementia) underwent auditory testing (peripheral and central abilities), cognitive testing and MR scanning (structural and diffusion-weighted sequences) to evaluate the relationship between hearing, cognition and imaging brain measures. RESULT: Central auditory measures such as speech-in-noise perception and auditory memory for longer durations were associated with cognitive impairment across the Alzheimer's disease continuum and specific auditory measures were independently associated with morphometric and diffusion-weighted brain measures. CONCLUSION: Auditory cognition could serve as a unique marker of cognition in Alzheimer's disease dementia and reflects imaging-derived brain changes potentially related to neurodegeneration.

Publication metadata

Author(s): Lad M, Griffiths T, Taylor J-P

Publication type: Article

Publication status: Published

Journal: Alzheimer's & Dementia

Year: 2024

Volume: 20

Issue: S3

Print publication date: 01/12/2024

Online publication date: 03/01/2025

Acceptance date: 02/04/2018

Date deposited: 21/01/2025

ISSN (print): 1552-5260

ISSN (electronic): 1552-5279

Publisher: John Wiley and Sons Inc.

URL: https://doi.org/10.1002/alz.089753

DOI: 10.1002/alz.089753

PubMed id: 39750436

Notes: Supplement: Clinical Manifestations

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