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Human Papillomavirus-Associated Multiphenotypic Carcinoma: First Description of a Vulval Case

Lookup NU author(s): Dr Charlotte CurrieORCiD, Dr Emma Spoor

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

Copyright © 2024 by the International Society of Gynecological Pathologists. Human papillomavirus (HPV)-associated multiphenotypic sinonasal carcinoma is a rare and recently described epithelial neoplasm exhibiting myoepithelial differentiation and morphological overlap with salivary gland neoplasms, especially adenoid cystic carcinoma; it is commonly associated with HPV, especially type 33. It has mainly been reported in the nasal cavity and paranasal sinuses with a single case reported in the breast. Herein, we report the first vulval example in a 47-year-old patient who presented with a large craggy mass in the region of the Bartholin gland. The histologic features were of a high-grade carcinoma composed of basaloid cells arranged in sheets and nests, with occasional ductal formations, surrounded by densely hyalinised basement membrane-type material. There was diffuse block-type immunoreactivity with p16 and HPV genotyping revealed high-risk HPV type 16. In reporting this case, we highlight the propensity for "salivary gland-type" neoplasms to arise in the vulva, especially in the Bartholin gland, and stress that pathologists should consider salivary-type neoplasms when faced with a morphologically unusual vulval tumor.

Publication metadata

Author(s): Currie CC, Leaning D, McCluggage WG, Spoor E

Publication type: Article

Publication status: Published

Journal: International Journal of Gynecological Pathology

Year: 2025

Volume: 44

Issue: 1

Pages: 37-41

Print publication date: 01/01/2025

Acceptance date: 02/04/2018

Date deposited: 13/02/2025

ISSN (print): 0277-1691

ISSN (electronic): 1538-7151

Publisher: Lippincott Williams & Wilkins

URL: https://doi.org/10.1097/PGP.0000000000001034

DOI: 10.1097/PGP.0000000000001034

PubMed id: 38661560

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