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The methylomic landscape of human articular cartilage development contains epigenetic signatures of osteoarthritis risk

Lookup NU author(s): Dr Matthew BarterORCiD, Abby Brumwell, Lynne Overman, Dr Tony Sorial, Professor David YoungORCiD, Dr Jamie Soul, Dr Sarah RiceORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Publication metadata

Author(s): McDonnell E, Orr SE, Barter MJ, Rux D, Brumwell A, Wrobel N, Murphy L, Overman LM, Sorial AK, Young DA, Soul J, Rice SJ

Publication type: Article

Publication status: Published

Journal: American Journal of Human Genetics

Year: 2024

Volume: 111

Issue: 12

Pages: 2756-2772

Print publication date: 05/12/2024

Online publication date: 22/11/2024

Acceptance date: 25/10/2024

Date deposited: 20/12/2024

ISSN (print): 0002-9297

ISSN (electronic): 1537-6605

Publisher: Cell Press

URL: https://doi.org/10.1016/j.ajhg.2024.10.017

DOI: 10.1016/j.ajhg.2024.10.017

Data Access Statement: Code used during this project are available on https://github.com/CBFLivUni/Epigenetics-OA-Risk-Human-Skeletal-Dev. Processed DNA methylation data for the 72 samples have been uploaded to the Gene Expression Omnibus. The accession number for the methylation data reported in this paper is GEO: GSE266461

PubMed id: 39579763

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Funding

Funder referenceFunder name
JGW Patterson Foundation
MRC Discovery Medicine North (DiMeN) Doctoral Training Partnership
MRC-Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA; MR/P020941/1 and MR/R502182/1)
NIH K99AR078352
Royal Society (RGS\R1\231319)
Royal College of Surgeons of England
UK-US Fulbright commission
Versus Arthritis Career Development Fellowship (22615)
Wellcome Trust

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