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PharmVar GeneFocus: CYP4F2

Lookup NU author(s): Emerita Professor Ann Daly

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).

Abstract

© 2024 The Author(s). Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.The Pharmacogene Variation Consortium (PharmVar) serves as a global repository providing star (*) allele nomenclature for the polymorphic human CYP4F2 gene. CYP4F2 genetic variation impacts the metabolism of vitamin K, which is associated with warfarin dose requirements, and the metabolism of drugs, such as imatinib or fingolimod, and certain endogenous compounds including vitamin E and eicosanoids. This GeneFocus provides a comprehensive overview and summary of CYP4F2 genetic variation including the characterization of 14 novel star alleles, CYP4F2*4 through *17. A description of how haplotype information cataloged by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC) is also provided.

Publication metadata

Author(s): Zubiaur P, Rodriguez-Antona C, Boone EC, Daly AK, Tsermpini EE, Khasawneh LQ, Sangkuhl K, Duconge J, Botton MR, Savieo J, Nofziger C, Whirl-Carrillo M, Klein TE, Gaedigk A

Publication type: Review

Publication status: Published

Journal: Clinical Pharmacology and Therapeutics

Year: 2024

Volume: 116

Issue: 4

Pages: 963-975

Print publication date: 01/10/2024

Online publication date: 13/08/2024

Acceptance date: 26/07/2024

ISSN (print): 0009-9236

ISSN (electronic): 1532-6535

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1002/cpt.3405

DOI: 10.1002/cpt.3405

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