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Parkinson's, where are we heading?

Lookup NU author(s): Professor Nicola PaveseORCiD, Dr David Ledingham

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Licence

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).

Abstract

© 2024 The Author(s). The prevalence of Parkinson’s disease has rapidly increased over the last decade. This editorial discusses our current understanding of the pathophysiological basis for the condition, with a particular focus on the potential role of α-synuclein, and the consequent implications this has for both the development of new investigations and disease-modifying therapies. Specifically, the article discusses the development of a new diagnostic test for cerebrospinal fluid α-synuclein, the development of a new staging system for Parkinson’s disease, which takes into account the α-synuclein, genetic and neuro-imaging status, and the results of two recently completed clinical trials, using monoclonal antibodies wherein α-synuclein is the principal target. We also discuss the increasing awareness of the importance of non-motor symptoms in Parkinson’s disease including hyposmia, rapid eye movement sleep behaviour disorder, and autonomic and cognitive symptoms.

Publication metadata

Author(s): Pavese N, Ledingham D

Publication type: Review

Publication status: Published

Journal: British Journal of Hospital Medicine

Year: 2024

Volume: 85

Issue: 7

Online publication date: 30/07/2024

Acceptance date: 01/07/2024

ISSN (print): 1750-8460

ISSN (electronic): 1759-7390

Publisher: MA Healthcare Ltd

URL: https://doi.org/10.12968/hmed.2024.0313

DOI: 10.12968/hmed.2024.0313

PubMed id: 39078897

Data Access Statement: All the data of this study are included in this article.

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