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Autophagy and lysosomal dysfunction in diabetes and its complications

Lookup NU author(s): Dr Catherine ArdenORCiD

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Abstract

© 2024 Elsevier Ltd. Autophagy is critical for energy homeostasis and the function of organelles such as endoplasmic reticulum (ER) and mitochondria. Dysregulated autophagy due to aging, environmental factors, or genetic predisposition can be an underlying cause of not only diabetes through β-cell dysfunction and metabolic inflammation, but also diabetic complications such as diabetic kidney diseases (DKDs). Dysfunction of lysosomes, effector organelles of autophagic degradation, due to metabolic stress or nutrients/metabolites accumulating in metabolic diseases is also emerging as a cause or aggravating element in diabetes and its complications. Here, we discuss the etiological role of dysregulated autophagy and lysosomal dysfunction in diabetes and a potential role of autophagy or lysosomal modulation as a new avenue for treatment of diabetes and its complications.

Publication metadata

Author(s): Arden C, Park SH, Yasasilka XR, Lee EY, Lee M-S

Publication type: Review

Publication status: Published

Journal: Trends in Endocrinology and Metabolism

Year: 2024

Volume: 35

Issue: 12

Pages: 1078-1090

Print publication date: 01/12/2024

Online publication date: 24/07/2024

Acceptance date: 02/04/2018

ISSN (print): 1043-2760

ISSN (electronic): 1879-3061

Publisher: Elsevier Inc.

URL: https://doi.org/10.1016/j.tem.2024.06.010

DOI: 10.1016/j.tem.2024.06.010

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