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Inflammatory memory in psoriasis: From remission to recurrence

Lookup NU author(s): Professor Muzlifah Haniffa

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2024 The AuthorsThe routine use of targeted systemic immunomodulatory therapies has transformed outcomes for people with severe psoriasis, with skin clearance (clinical remission) rates up to 60% at 1 year of biologic treatment. However, psoriasis may recur following drug withdrawal, and as a result, patients tend to continue receiving costly treatment indefinitely. Here, we review research into the “inflammatory memory” in resolved psoriasis skin and the potential mechanisms leading to psoriasis recurrence following drug withdrawal. Research has implicated immune cells such as tissue resident memory T cells, Langerhans cells, and dermal dendritic cells, and there is growing interest in keratinocytes and fibroblasts. A better understanding of the interactions between these cell populations, enabled by single cell technologies, will help to elucidate the events underpinning the shift from remission to recurrence. This may inform the development of personalized strategies for sustaining remission while reducing long-term drug burden.

Publication metadata

Author(s): Francis L, Capon F, Smith CH, Haniffa M, Mahil SK

Publication type: Review

Publication status: Published

Journal: Journal of Allergy and Clinical Immunology

Year: 2024

Volume: 154

Issue: 1

Pages: 42-50

Online publication date: 17/05/2024

Acceptance date: 14/05/2024

ISSN (print): 0091-6749

ISSN (electronic): 1097-6825

Publisher: Elsevier Inc.

URL: https://doi.org/10.1016/j.jaci.2024.05.008

DOI: 10.1016/j.jaci.2024.05.008

PubMed id: 38761994

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