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Locating the ventral intermediate thalamic nucleus for deep brain stimulation surgery: analysis of a case series comparing CT and MR targeting

Lookup NU author(s): Melissa Gough, Dr Alistair Jenkins

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Background: Deep brain stimulation (DBS) surgery targeting the ventral intermediate thalamic nucleus (Vim) has proven efficacy in the treatment of tremor. Aims: The primary aim is to investigate whether there is a statistically significant difference in patient outcomes when CT-guided targeting of the Vim is compared with MRI-guided targeting. Methods: This is a retrospective study concerning patients undergoing Vim-targeted DBS at the Department of Neurosurgery, Royal Victoria Infirmary in Newcastle (9th August 2012 to 4th January 2019). Fahn–Tolosa–Marin Tremor Scale (FTM TS) and EQ-5D scores were collected from patient notes. Statistical analysis was performed using IBM® SPSS® Statistics Version 24. Independent samples t-tests were used to compare means. Results: Independent samples t-test did not reveal a statistically significant difference between CT (n = 10; FTM TS mean = 65.40, SD = 11.40; EQ-5D mean = 39.50, SD = 17.87) and MR (n = 7; FTM TS mean = 60.57, SD = 7.50; EQ-5D mean = 32.14, SD = 9.94) groups in pre-surgery FTM TS (t(15) = 0.977, p = 0.344) and EQ-5D (t(15) = 0.982, p = 0.342) scores. No statistically significant difference between the CT (FTM TS mean = 24.12, SD = 20.47; EQ-5D mean = 75.56, SD = 15.63) and MR (FTM TS mean = 22.86, SD = 6.72; EQ-5D mean = 70.43, SD = 15.48) groups was revealed at 1 year assessment of FTM TS (t(14) = 0.155, p = 0.879) and EQ-5D (t(14) = 0.654, p = 0.524). The median difference between pre- and post-surgery FTM TS and EQ-5D scores in the CT group at 1 year was 43.00 and 35.00, respectively. The MR patient group median difference in pre- and post-surgery at 1 year was 35.00 and 35.00 respectively. Conclusion: No statistically significant difference between CT and MR image-guided targeting patient groups was detected.

Publication metadata

Author(s): Gough M, Mills R, Brechany U, Nicholson C, Jenkins A, Hussain MA

Publication type: Article

Publication status: Published

Journal: British Journal of Neurosurgery

Year: 2025

Volume: 39

Issue: 5

Pages: 642-647

Online publication date: 19/02/2024

Acceptance date: 27/01/2024

Date deposited: 10/04/2024

ISSN (print): 0268-8697

ISSN (electronic): 1360-046X

Publisher: Taylor and Francis Ltd

URL: https://doi.org/10.1080/02688697.2024.2313674

DOI: 10.1080/02688697.2024.2313674

PubMed id: 38372013

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