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Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers

Lookup NU author(s): Dr Ute JungwirthORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2022 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd.Skin cancers are by far the most frequently diagnosed human cancers. The closely related transcriptional co-regulator proteins YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation, progression and metastasis in melanoma and non-melanoma skin cancers. YAP/TAZ serve as an essential signalling hub by integrating signals from multiple upstream pathways. In this review, we summarize the roles of YAP/TAZ in skin physiology and tumorigenesis and discuss recent efforts of therapeutic interventions that target YAP/TAZ in in both preclinical and clinical settings, as well as their prospects for use as skin cancer treatments.

Publication metadata

Author(s): Howard A, Bojko J, Flynn B, Bowen S, Jungwirth U, Walko G

Publication type: Review

Publication status: Published

Journal: Experimental Dermatology

Year: 2022

Volume: 31

Issue: 10

Pages: 1477-1499

Print publication date: 01/10/2022

Online publication date: 01/08/2022

Acceptance date: 25/07/2022

ISSN (print): 0906-6705

ISSN (electronic): 1600-0625

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1111/exd.14655

DOI: 10.1111/exd.14655

PubMed id: 35913427

Data Access Statement: Data sharing is not applicable to this article as no new data were created or analyzed in this study.

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