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High-throughput single-cell analysis reveals progressive mitochondrial DNA mosaicism throughout life

Lookup NU author(s): Dr Jim StewartORCiD, Professor Patrick Chinnery

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Author(s): Glynos A, Bozhilova LV, Frison M, Burr S, Stewart JB, Chinnery PF

Publication type: Article

Publication status: Published

Journal: Science Advances

Year: 2023

Volume: 9

Issue: 43

Online publication date: 25/10/2023

Acceptance date: 21/09/2023

Date deposited: 23/11/2023

ISSN (electronic): 2375-2548

Publisher: American Association for the Advancement of Science (AAAS)

URL: https://doi.org/10.1126/sciadv.adi4038

DOI: 10.1126/sciadv.adi4038

Data Access Statement: The heteroplasmy data and code required to reproduce the analysis presented in the figures above are available in GitHub repository: https://github.com/lbozhilova/sc-mtdna-mosaicism; and the general-purpose open repository Zenodo: https://zenodo.org/record/8200085. The m.5024C>T and m.5019A>G mice can be provided by J.B.S. to academic laboratories, pending scientific review, and a completed MTA. Requests for these mice should be submitted directly to J.B.S.

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