Obesity and Type 2 Diabetes

Zhyzhneuskaya, S; Taylor, R

doi:10.1007/978-3-319-46933-1_21

Obesity and Type 2 Diabetes

Lookup NU author(s): Dr Sviatlana Zhyzhneuskaya, Emeritus Professor Roy Taylor ORCiD

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Abstract

© 2019, Springer Nature Switzerland AG. This chapter separately describes the pathophysiology of type 2 diabetes and that of obesity, and identifies the relationship between these states. The important concept of long-term reversibility of type 2 diabetes is discussed along with the beta-cell dedifferentiation, which explains the insulin secretory defect. Obesity brings about distinct pathophysiological changes as a consequence of individuals’ pattern of food intake and levels of activity. The practical issue of clinical management is considered with particular reference to the weight management goals for type 2 diabetes. Following therapeutic weight loss in both conditions, long-term avoidance of weight regain is vital and is optimally achieved by a combination of ongoing food energy restriction and daily physical activity.