Toggle Main Menu Toggle Search

Open Access padlockePrints

The Newcastle University research output collection, currently available on ePrints, will shortly be moving to a new open repository platform, Figshare. To prepare for the data migration we have paused adding new content to ePrints, and will resume once the new repository is launched. During this time you will continue to have access to ePrints (but no new content will appear). We will share updates here when available.

Sleep disorders in Lewy body dementia: Mechanisms, clinical relevance, and unanswered questions

Lookup NU author(s): Dr Leigh TownsendORCiD, Dr Kirstie Anderson, Emeritus Professor Ian McKeith, Professor John-Paul TaylorORCiD

Downloads

Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. In Lewy body dementia (LBD), disturbances of sleep and/or arousal including insomnia, excessive daytime sleepiness, rapid eye movement (REM) sleep behavior disorder, obstructive sleep apnea, and restless leg syndrome are common. These disorders can each exert a significant negative impact on both patient and caregiver quality of life; however, their etiology is poorly understood. Little guidance is available for assessing and managing sleep disorders in LBD, and they remain under-diagnosed and under-treated. This review aims to (1) describe the specific sleep disorders which occur in LBD, considering their putative or potential mechanisms; (2) describe the history and diagnostic process for these disorders in LBD; and (3) summarize current evidence for their management in LBD and consider some of the ongoing and unanswered questions in this field and future research directions.

Publication metadata

Author(s): Townsend LTJ, Anderson KN, Boeve BF, McKeith I, Taylor J-P

Publication type: Review

Publication status: Published

Journal: Alzheimer's and Dementia

Year: 2023

Volume: 19

Issue: 11

Pages: 5264-5283

Print publication date: 01/11/2023

Online publication date: 01/07/2023

Acceptance date: 26/05/2023

ISSN (print): 1552-5260

ISSN (electronic): 1552-5279

Publisher: John Wiley and Sons Inc

URL: https://doi.org/10.1002/alz.13350

DOI: 10.1002/alz.13350

PubMed id: 37392199

Share