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Impact of PNPLA3 rs738409 Polymorphism on the Development of Liver-Related Events in Patients With Nonalcoholic Fatty Liver Disease

Lookup NU author(s): Dr Olivier GovaereORCiD, Professor Quentin AnsteeORCiD

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Abstract

© 2023 AGA InstituteBackground and Aims: Nonalcoholic fatty liver disease (NAFLD) is a complex disease, resulting from the interplay between environmental determinants and genetic variations. Single nucleotide polymorphism rs738409 C>G in the PNPLA3 gene is associated with hepatic fibrosis and with higher risk of developing hepatocellular carcinoma. Here, we analyzed a longitudinal cohort of biopsy-proven NAFLD subjects with the aim to identify individuals in whom genetics may have a stronger impact on disease progression. Methods: We retrospectively analyzed 756 consecutive, prospectively enrolled biopsy-proven NAFLD subjects from Italy, United Kingdom, and Spain who were followed for a median of 84 months (interquartile range, 65–109 months). We stratified the study cohort according to sex, body mass index (BMI)

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Author(s): Rosso C, Caviglia GP, Birolo G, Armandi A, Pennisi G, Pelusi S, Younes R, Liguori A, Perez-Diaz-del-Campo N, Nicolosi A, Govaere O, Castelnuovo G, Olivero A, Abate ML, Ribaldone DG, Fariselli P, Valenti L, Miele L, Petta S, Romero-Gomez M, Anstee QM, Bugianesi E

Publication type: Article

Publication status: Published

Journal: Clinical Gastroenterology and Hepatology

Year: 2023

Volume: 21

Issue: 13

Print publication date: 01/12/2023

Online publication date: 04/05/2023

Acceptance date: 02/04/2023

ISSN (print): 1542-3565

ISSN (electronic): 1542-7714

Publisher: Elsevier

URL: https://doi.org/10.1016/j.cgh.2023.04.024

DOI: 10.1016/j.cgh.2023.04.024

PubMed id: 37149016

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