ePrints

Treadmill exercise modulates nigral and hippocampal cannabinoid receptor type 1 in the 6-OHDA model of Parkinson’s disease

Lookup NU author(s): Professor David BrooksORCiD

Downloads

• Published version [.pdf]

Licence

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

Physical exercise benefits Parkinson’s disease (PD) patients but the mechanism is unclear. Cannabinoid receptor type 1 (CB1R) is known to be reduced in PD patients and animal models. We test the hypothesis that binding of the CB1R inverse agonist, [³H]SR141716A, is normalized by treadmill exercise in the toxin-induced 6-hydroxdopamine (6-OHDA) model of PD. Male rats had unilateral striatal injections of 6-OHDA or saline. After 15 days, half were submitted to exercise and half remained sedentary. [³H]SR141716A autoradiography was performed in postmortem tissue from striatum, substantia nigra (SN) and hippocampus. There was a 41% decrease of [³H]SR141716A specific binding in the ipsilateral SN of 6-OHDA-injected sedentary animals which was attenuated to 15% by exercise, when compared to saline-injected animals. No striatal differences were observed. A 30% bilateral hippocampal increase was observed in both healthy and 6-OHDA exercised groups. In addition, a positive correlation between nigral [³H]SR141716A binding and nociceptive threshold was observed in PD-exercised animals (p=0.0008), suggesting a beneficial effect of exercise in the pain associated with the model. Chronic exercise can reduce the detrimental effects of PD on nigral [³H]SR141716A binding, similar to the reported reduction after dopamine replacement therapy, so should be considered as an adjunct therapy for PD.

Publication metadata

Author(s): Binda KH, Landau AM, Chacur M, Brooks DJ, Real CC

Publication type: Article

Publication status: Published

Journal: Brain Research

Year: 2023

Volume: 1814

Print publication date: 01/09/2023

Online publication date: 01/06/2023

Acceptance date: 29/05/2023

Date deposited: 12/06/2023

ISSN (print): 0006-8993

ISSN (electronic): 1872-6240

Publisher: Elsevier BV

URL: https://doi.org/10.1016/j.brainres.2023.148436

DOI: 10.1016/j.brainres.2023.148436

Altmetrics

Funding

Share