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Synthetic Strategies to Control C–N Atropisomerism in Acyclic Amines and Amides

Lookup NU author(s): Aaron Campbell, Dr Roly ArmstrongORCiD

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Abstract

Atropisomeric molecules are a privileged class of stereogenic material that have important applications in catalysis, materials science and medicines. To date, the majority of work has been focused upon biaryl and heterobiaryl scaffolds involving restricted rotation between a pair of cyclic fragments, but C–N atropisomeric molecules based upon amines and amides where the nitrogen atom is not part of a ring system are rapidly emerging as an important class of stereogenic molecules. This is the focus of this Short Review article, which begins by discussing the factors which influence the configurational stability of such molecules and provides a historical background to their synthesis. This is followed by a detailed discussion of state-of-the-art catalytic asymmetric strategies that are now available to access C–Nacyclic atropisomers including carboxamides, sulfonamides, sulfinamides, phosphamides and diarylamines. A variety of different synthetic approaches are discussed including kinetic resolution/desymmetrization, amination, C–H functionalization, N-functionalization, and annulation.

Publication metadata

Author(s): Campbell ADG, Armstrong RJ

Publication type: Article

Publication status: Published

Journal: Synthesis

Year: 2023

Volume: 55

Online publication date: 21/02/2023

Acceptance date: 20/02/2023

Date deposited: 21/02/2023

ISSN (electronic): 0039-7881

Publisher: Thieme

URL: https://doi.org/10.1055/a-2039-5424

DOI: 10.1055/a-2039-5424

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