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Complete representation of a tapeworm genome reveals chromosomes capped by centromeres, necessitating a dual role in segregation and protection

Lookup NU author(s): Dr Katherine JamesORCiD

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Abstract

Chromosome-level assemblies are indispensable for accurate gene prediction, synteny assessment, and understanding higher-order genome architecture. Reference and draft genomes of key helminth species have been published, but little is yet known about the biology of their chromosomes. Here, we present the complete genome of the tapeworm Hymenolepis microstoma, providing a reference quality, end-to-end assembly that represents the first fully assembled genome of a spiralian/lophotrochozoan, revealing new insights into chromosome evolution.

Publication metadata

Author(s): Olson PD, Tracey A, Baillie A, James K, Doyle SR, Buddenborg SK, Rodgers FH, Holroyd N, Berriman M

Publication type: Article

Publication status: Published

Journal: BMC Biology

Year: 2020

Volume: 18

Online publication date: 09/11/2020

Acceptance date: 14/10/2020

Date deposited: 06/06/2025

ISSN (electronic): 1741-7007

Publisher: BioMed Central Ltd

URL: https://doi.org/10.1186/s12915-020-00899-w

DOI: 10.1186/s12915-020-00899-w

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