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A systematic review and meta-analysis of sleep and circadian rhythms disturbances in individuals at high-risk of developing or with early onset of bipolar disorders

Lookup NU author(s): Emeritus Professor Jan Scott

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Abstract

© 2022. Sleep and circadian rhythms disturbances (SCRD) in young people at high risk or with early onset of bipolar disorders (BD) are poorly understood. We systematically searched for studies of self, observer or objective estimates of SCRD in asymptomatic or symptomatic offspring of parents with BD (OSBD), individuals with presentations meeting recognised BD-at-risk criteria (BAR) and youth with recent onset of full-threshold BD (FT-BD). Of 76 studies eligible for systematic review, 35 (46%) were included in random effects meta-analyses. Pooled analyses of self-ratings related to circadian rhythms demonstrated greater preference for eveningness and more dysregulation of social rhythms in BAR and FT-BD groups; analyses of actigraphy provided some support for these findings. Meta-analysis of prospective studies showed that pre-existing SCRD were associated with a 40% increased risk of onset of BD, but heterogeneity in assessments was a significant concern. Overall, we identified longer total sleep time (Hedges g: 0.34; 95% confidence intervals:.1, .57), especially in OSBD and FT-BD and meta-regression analysis indicated the effect sizes was moderated by the proportion of any sample manifesting psychopathology or receiving psychotropic medications. This evolving field of research would benefit from greater attention to circadian rhythm as well as sleep quality measures.

Publication metadata

Author(s): Scott J, Etain B, Miklowitz D, Crouse JJ, Carpenter J, Marwaha S, Smith D, Merikangas K, Hickie I

Publication type: Review

Publication status: Published

Journal: Neuroscience and Biobehavioral Reviews

Year: 2022

Volume: 135

Print publication date: 01/04/2022

Online publication date: 17/02/2022

Acceptance date: 13/02/2022

ISSN (print): 0149-7634

ISSN (electronic): 1873-7528

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/j.neubiorev.2022.104585

DOI: 10.1016/j.neubiorev.2022.104585

PubMed id: 35182537

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