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Monitoring the safety of COVID-19 vaccination in pregnancy in the UK: A national study using the UK Obstetric Surveillance System (UKOSS), UK Teratology Information Service (UKTIS) and Vaccination in Pregnancy (VIP) safety monitoring systems

Lookup NU author(s): Dr Jonathan Richardson, Dr Sally Stephens, Dr Kenneth Hodson

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Abstract

© The Author(s) 2022. Background: COVID-19 vaccines are protective against disease. Pregnant women benefit from vaccination as they are at higher risk of poor maternal and neonatal outcomes following infection. Methods: Following regulatory approval of two COVID-19 vaccines in the United Kingdom, a rapid national study of vaccination in pregnancy was instituted using three existing safety surveillance platforms: UKOSS, UKTIS and VIP. This preliminary report describes the data collected up to the 15th June 2021. Results: There were 971 reports of COVID-19 vaccination in the UKOSS/UKTIS (n = 493) and VIP (n = 478) monitoring systems describing 908 individual pregnancies. Pfizer-BioNTech mRNA vaccination was most common (n = 501, 55.2%), most women were vaccinated in their second or third trimester (n = 566, 62.3%), and were mainly vaccinated due to occupational infection risk (n = 577, 63.5%). Conclusion: Obstetric outcome data will be obtained by December 2021. However, women should not delay vaccination whilst awaiting further safety data to emerge.

Publication metadata

Author(s): Richardson JL, Stephens S, Chappell LC, Campbell H, Amirthalingam G, O'Boyle S, Bukasa A, Knight M, Hodson KK

Publication type: Article

Publication status: Published

Journal: Obstetric Medicine

Year: 2023

Volume: 16

Issue: 1

Pages: 40-47

Print publication date: 01/03/2023

Online publication date: 08/02/2022

Acceptance date: 02/01/2022

ISSN (print): 1753-495X

ISSN (electronic): 1753-4968

Publisher: SAGE Publications Inc.

URL: https://doi.org/10.1177/1753495X221076713

DOI: 10.1177/1753495X221076713

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