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Opportunities and challenges of macrogenetic studies

Lookup NU author(s): Dr Evelyn JensenORCiD

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Abstract

© 2021, Springer Nature Limited.The rapidly emerging field of macrogenetics focuses on analysing publicly accessible genetic datasets from thousands of species to explore large-scale patterns and predictors of intraspecific genetic variation. Facilitated by advances in evolutionary biology, technology, data infrastructure, statistics and open science, macrogenetics addresses core evolutionary hypotheses (such as disentangling environmental and life-history effects on genetic variation) with a global focus. Yet, there are important, often overlooked, limitations to this approach and best practices need to be considered and adopted if macrogenetics is to continue its exciting trajectory and reach its full potential in fields such as biodiversity monitoring and conservation. Here, we review the history of this rapidly growing field, highlight knowledge gaps and future directions, and provide guidelines for further research.

Publication metadata

Author(s): Leigh DM, van Rees CB, Millette KL, Breed MF, Schmidt C, Bertola LD, Hand BK, Hunter ME, Jensen EL, Kershaw F, Liggins L, Luikart G, Manel S, Mergeay J, Miller JM, Segelbacher G, Hoban S, Paz-Vinas I

Publication type: Review

Publication status: Published

Journal: Nature Reviews Genetics

Year: 2021

Volume: 22

Pages: 791-807

Online publication date: 18/08/2021

Acceptance date: 24/06/2021

ISSN (print): 1471-0056

ISSN (electronic): 1471-0064

Publisher: Nature Research

URL: https://doi.org/10.1038/s41576-021-00394-0

DOI: 10.1038/s41576-021-00394-0

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